The endocannabinoid system

What is the endocannabinoid system and how does it work?
A summary of various known and unknown sources from the Internet.

One of the latest and most striking scientific discoveries. ECS regulates a variety of biological processes such as relaxation, nutrition, sleep, certain inflammatory reactions and even cognitive functions. In short, your ECS is responsible for the optimal function of your body. This is not an easy task!

Endocannabinoids and their receptors are found throughout the body. However, while the endocannabinoid system performs its functions, the ECS acts as a regulator of homeostasis, according to experts. Such a complex system as the ECS is difficult to define. However, it is important to know that there are two important receptors in the body cells: CB1 and CB2. They are abundant in the brain and immune system. The body produces cannabinoids in a natural process (e.g. endocannabinoids: anandamides and 2-AG), which have similar chemical structures to cannabinoids of plant origin as CBD.







Scientists first discovered the endocannabinoid system when they tried to understand the effects of cannabis on humans. While much is still unknown about this system, we know that our body has many cannabinoid receptors and produces molecules that are responsible for the physical and psychological effects of cannabis in our body. Have you ever wondered why cannabis can act so effectively on your body? Well, it’s this system!

Since its discovery, the endocannabinoid system has become a priority object of medical research because of its enormous effects and therapeutic potential for the human body.

Endocannabinoids (and plant cannabinoids) combine with receptors called cannabinoid receptors on the cell surface. There are two main receptors, CB1 and CB2, and cannabidiol (CBD) has been shown to strengthen and increase the efficiency of mitochondria, which are the driving force for every cell in your body. Studies on the endocannabinoid system (ECS) have shown that in addition to its role as a regulator of homeostasis, ECS is also responsible for the repair of damaged cells. The investigations also show that cannabinoids are able to specifically recognise damaged cells without influencing healthy cells. This means that the ECS can act as a biological defence system. When a person ingests hemp oil, CBD or other cannabinoids, these cannabinoid receptors are activated (the CBD seems to have a higher affinity for CB2 receptors than for CB1 receptors). Research suggests that supplementing your ECS with non-toxic and non-addictive cannabinoids will make it possible to develop a healthier endocannabinoid system and almost certainly a healthier lifestyle.

The two major endocannabinoids that are well understood today are:

Anandamide: The first endocannabinoid discovered by scientists. His name comes from the Sanskrit word “Ananda”, which means “bliss”. It is found in higher concentrations in body regions remote from the brain.

2-AG (2-eachidonoylglycerin): Highest concentrations occur in the brain.

These endocannabinoids are called “short-term” neurotransmitters because they are only synthesized when the body signals that it needs them acutely. After their release, they are rapidly degraded by enzymes such as FAAH (fatty acid amide hydrolase) and MAGL (monoacylglycerol lipase). There are many other endocannabinoids such as noladine ether, virodhamin and N-arachidonoyldopamine (NADA). However, their role in the body has not yet been fully decoded.

The body produces endocannabinoids to trigger essential physical functions and patterns. Ethan Russo, a senior consultant at GW Pharmaceuticals, believes that “deficient cannabinoid levels can be the underlying cause of many diseases. This deficiency could possibly cause severe diseases such as chronic pain or fibromyalgia associated with the endocannabinoid system.


CBD does not actually bind to any receptors, but instead acts as an inhibitor of the enzyme FAAH, which slows down or prevents the degradation of anandamide – possibly one of the most important endocannabinoids in the body. The result is a build-up of anandamide in the brain.

While we are aware that THC has an obvious psychological effect on the mind, CBD is considered effective on the physiological level, although we have only just begun to discover its medical benefits. However, it is well known that CBD helps in the treatment of serious medical conditions, including inhibition of tumor growth, reduction or prevention of inflammation and nausea, diabetes, PTSD, schizophrenia, rheumatoid arthritis, epilepsy, cardiovascular disease, psychosis, anxiety disorders and even as a pain reliever for muscle spasms or neuropathic pain.

Researchers are studying cannabinoids and other compounds to see how they interact with the endocannabinoid system.
CBD and THC are not the only compounds used by the endocannabinoid system. There are at least eighty phyto-cannabinoids, different endocannabinoids. These are the cannabinoids that all mammals produce in their bodies, as well as some other compounds, such as omega fatty acids, that interact with cannabinoid receptors.

Thousands of studies have been published and reviewed on the subject of the endocannabinoid system. Since its discovery more than two decades ago, the endocannabinoid system has aroused interest in pharmaceutical drug development and research. In general, this research shows that the endocannabinoid system seems to play a strongly “protective” role in our body. In fact, the most important thing the endocannabinoid system wants to protect is homeostasis – that is, ensuring that the body functions optimally at all times. Some researchers have suggested an “endocannabinoides syndrome”, a syndrome in which the body does not produce enough endocannabinoids. This research speculates that a lack of cannabinoids may be related to autoimmune diseases such as lupus, rheumatoid arthritis, diabetes and many more.
As a company, Kannaway is absolutely committed to research into the endocannabinoid system. If research continues in the current direction, it can be argued that the endocannabinoid system is a key system for the general well-being of humans!

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Freely reproduced translations of various articles